1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine

Base Information

• Chemical Name: 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine
• CAS No.: 1311157-67-1
• Molecular Formula: C₂₄H₃₀N₂O₃
• Molecular Weight: 394.514

Synonyms:1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine

Chemical Property of 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine

Chemical Property:

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Technology Process of 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine

There total 3 articles about 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxy-4-(pent-4-yn-1-yloxy)benzaldehyde (1001289-60-6) + 1-(2-Methoxyphenyl)piperazine (35386-24-4) → 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine (1311157-67-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm2004859

Reference yield:

1-chloro-4-pentyne (14267-92-6) → 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine (1311157-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 16 h / Reflux

2: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1021/jm2004859

Reference yield:

vanillin (121-33-5,8014-42-4) → 1-{[3-methoxy-4-(pent-4-yn-1-yloxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine (1311157-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 16 h / Reflux

2: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1021/jm2004859

upstream raw materials:

3-methoxy-4-(pent-4-yn-1-yloxy)benzaldehyde

1-(2-Methoxyphenyl)piperazine

1-chloro-4-pentyne

vanillin

Downstream raw materials:

1-{[3-methoxy-4-(3-{1-[8-(4-propyl-1H-1,2,3-triazole-1-yl)octyl]-1H-1,2,3-triazole-4-yl}propoxy)phenyl]methyl}-4-(2-methoxyphenyl)piperazine

C₅₀H₇₂N₁₀O₅

C₅₅H₈₀N₁₀O₅

1-[(4-{3-[1-(2-ethoxyethyl)-1H-1,2,3-triazole-4-yl]propoxy}-3-methoxyphenyl)methyl]-4-(2-methoxyphenyl)piperazine

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