1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

Base Information

Chemical Name:1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine
CAS No.:130985-85-2
Molecular Formula:C₁₇H₁₇ClN₆
Molecular Weight:340.815
Hs Code.:

Synonyms:1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

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Chemical Property of 1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

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Technology Process of 1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

There total 1 articles about 1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130985-84-1
1,3-diamino-9-benzyl-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridin-6(5H,9H)-one hydrochloride

: 130985-85-2
1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

Guidance literature:: With thionyl chloride; ethanol; water; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) CHCl₃, reflux, 5 h, 2.) RT 24 h;
DOI:10.1021/jm00106a022

Reference yield: 84.0%

: 130985-85-2
1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

: 131010-65-6
3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

Guidance literature:: With hydrogenchloride; for 1.5h; Heating;
DOI:10.1021/jm00106a022

Reference yield:

: 130985-85-2
1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

: 1211306-46-5
cis-5,11-methylenetetrahydro-5-deazahomofolate

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / H₂, conc. HCl/H₂O/i-PrOH / 10percent Pd/C / 6 h / 760 Torr / Ambient temperature

2: H₂ / Pt₂O / trifluoroacetic acid; H₂O / 24 h / 2585.7 Torr / Ambient temperature

3: 78.5 percent / K₂CO₃ / dimethylsulfoxide / 10 h / 120 °C

4: trifluoroacetic acid (TFA) / 1.5 h / Ambient temperature

6: 1 N NaOH / 2-methoxy-ethanol / 8 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; water; hydrogen; potassium carbonate; isopropyl alcohol; trifluoroacetic acid; palladium on activated charcoal; Adam’s catalyst; In 2-methoxy-ethanol; water; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1021/jm00106a022