N^b-benzyl-D-nordeethylvincadifformine

Base Information

• Chemical Name: N^b-benzyl-D-nordeethylvincadifformine
• CAS No.: 77080-62-7
• Molecular Formula: C₂₃H₂₄N₂O₂
• Molecular Weight: 360.456
• Mol file: 77080-62-7.mol

Synonyms:N^b-benzyl-D-nordeethylvincadifformine

Chemical Property of N^b-benzyl-D-nordeethylvincadifformine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^b-benzyl-D-nordeethylvincadifformine

There total 2 articles about N^b-benzyl-D-nordeethylvincadifformine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

acetaldehyde (75-07-0,9002-91-9) + methyl 3-benzyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate (66859-30-1) → Nb-benzyl-D-nordeethylvincadifformine (77080-62-7)

Guidance literature:

In toluene; for 1h; Heating;

DOI:10.1021/jo00067a061

Reference yield:

benzyl bromide (100-39-0) + C16H18N2O2 (77080-59-2,77122-13-5) → methyl 3-benzyl-1,2,3,3a,4,5-hexahydro-7H-pyrrolo(2,3-d)carbazole-6-carboxylate (77080-62-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.) CHCl₃, 20 h, reflux, 2.) 6 d, reflux;

DOI:10.1021/jo00323a007

Reference yield: 84.0%

Nb-benzyl-D-nordeethylvincadifformine (77080-62-7) → Nb-benzyl-16-(methoxycarbonyl)-D-norcleavamine (132751-13-4)

Guidance literature:

With sodium tetrahydroborate; acetic acid; at 90 ℃;

DOI:10.1021/jo00008a024

upstream raw materials:

benzyl bromide

C₁₆H₁₈N₂O₂

acetaldehyde

methyl 3-benzyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate

Downstream raw materials:

N^b-benzyl-16-(methoxycarbonyl)-D-norcleavamine