4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde

Base Information

• Chemical Name: 4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde
• CAS No.: 853730-80-0
• Molecular Formula: C₁₈H₁₉NOS
• Molecular Weight: 297.421

Synonyms:4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde

Chemical Property of 4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde

Chemical Property:

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Technology Process of 4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde

There total 2 articles about 4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chloro-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde (853730-77-5) + ethanethiol (75-08-1) → 4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde (853730-80-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2008.10.002

Reference yield:

2-methyl-1-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one (72211-20-2) → 4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde (853730-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / CH₂Cl₂ / 0.08 h / Heating

2: K₂CO₃ / dimethylformamide / 20 °C

With potassium carbonate; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.03.016

Reference yield: 85.0%

4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde (853730-80-0) → 4-(ethylsulfanyl)-2-methyl-1-phenyl-1H-indole-5-carbaldehyde (853730-83-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 0.25h; Reflux;

DOI:10.1016/j.bmc.2008.10.002

upstream raw materials:

4-chloro-2-methyl-1-phenyl-6,7-dihydro-1H-indole-5-carbaldehyde

ethanethiol

2-methyl-1-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one

Downstream raw materials:

4-(ethylsulfanyl)-2-methyl-1-phenyl-1H-indole-5-carbaldehyde

ethyl 3-[4-(ethylsulfanyl)-2-methyl-1-phenyl-6,7-dihydro-1H-indol-5-yl]acrylate

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