5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine
• CAS No.: 1404457-38-0
• Molecular Formula: C₄₉H₄₁N₅O₇
• Molecular Weight: 811.894

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-pyrenyl azide (36171-39-8) + 5'-O-(4,4'-dimethoxytrityl)-2'-(prop-2-yn-1-yl)-2'-deoxyuridine (1404457-37-9) → 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine (1404457-38-0)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo301571s

Reference yield:

2'-deoxy-2'-C-(prop-2-yn-yl)uridine (1360627-86-6) → 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine (1404457-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulfate / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With pyridine; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1021/jo301571s

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine (1404457-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulfate / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With pyridine; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1021/jo301571s

upstream raw materials:

2'-deoxy-2'-C-(prop-2-yn-yl)uridine

4,4'-dimethoxytrityl chloride

1-pyrenyl azide

5'-O-(4,4'-dimethoxytrityl)-2'-(prop-2-yn-1-yl)-2'-deoxyuridine

Downstream raw materials:

3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

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