3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

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Chemical Name:3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine
CAS No.:1404457-39-1
Molecular Formula:C₅₈H₅₈N₇O₈P
Molecular Weight:1012.11
Hs Code.:

Synonyms:3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

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Chemical Property of 3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

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Technology Process of 3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

There total 3 articles about 3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1404457-38-0
5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1404457-39-1
3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo301571s

Reference yield:

: 1360627-86-6
2'-deoxy-2'-C-(prop-2-yn-yl)uridine

: 1404457-39-1
3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulfate / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo301571s

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1404457-39-1
3'-O-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-((1-(pyren-1-yl)-1,2,3-triazole-4-yl)methyl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulfate / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo301571s