C₄₀H₄₄Cl₃NO₈S

Base Information

Chemical Name:C₄₀H₄₄Cl₃NO₈S
CAS No.:1262848-08-7
Molecular Formula:C₄₀H₄₄Cl₃NO₈S
Molecular Weight:805.216
Hs Code.:

C<sub>40</sub>H<sub>44</sub>Cl<sub>3</sub>NO<sub>8</sub>S

Synonyms:C₄₀H₄₄Cl₃NO₈S

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Chemical Property of C₄₀H₄₄Cl₃NO₈S

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Technology Process of C₄₀H₄₄Cl₃NO₈S

There total 11 articles about C₄₀H₄₄Cl₃NO₈S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1262848-31-6
C₃₉H₄₂Cl₃NO₆

: 124-63-0
methanesulfonyl chloride

: 1262848-08-7
C₄₀H₄₄Cl₃NO₈S

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ol102856j

Reference yield:

: 160836-05-5
C₂₁H₂₆O₅

: 1262848-08-7
C₄₀H₄₄Cl₃NO₈S

Guidance literature:: Multi-step reaction with 11 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 4 h / -5 - 0 °C / Inert atmosphere

2: 2,6-di-tert-butyl-4-methyl-phenol / tert-butylbenzene / 27 h / 180 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dichloro-ethane / 3 h / 40 °C / Inert atmosphere

4: methanesulfonamide; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane] / water; tert-butyl alcohol / 62 h / 0 °C / Inert atmosphere

5: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

6: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 0.83 h / 20 °C / Inert atmosphere

7: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

8: magnesium bromide ethyl etherate / dichloromethane / 40 h / -10 °C / Inert atmosphere

9: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere

10: hydrogenchloride; water / methanol / 16 h / 20 °C

11: triethylamine / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; oxalyl dichloride; methanesulfonamide; 2,6-di-tert-butyl-4-methyl-phenol; water; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium bromide ethyl etherate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; In methanol; tert-butylbenzene; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Overman rearrangement / 4: Sharpless dihydroxylation / 7: Swern oxidation / 8: Hosomi-Sakurai allylation;
DOI:10.1021/ol102856j

Reference yield:

: 1262848-10-1
C₂₃H₂₆Cl₃NO₅

: 1262848-08-7
C₄₀H₄₄Cl₃NO₈S

Guidance literature:: Multi-step reaction with 9 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dichloro-ethane / 3 h / 40 °C / Inert atmosphere

2: methanesulfonamide; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane] / water; tert-butyl alcohol / 62 h / 0 °C / Inert atmosphere

3: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 0.83 h / 20 °C / Inert atmosphere

5: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

6: magnesium bromide ethyl etherate / dichloromethane / 40 h / -10 °C / Inert atmosphere

7: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere

8: hydrogenchloride; water / methanol / 16 h / 20 °C

9: triethylamine / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; oxalyl dichloride; methanesulfonamide; water; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium bromide ethyl etherate; dimethyl sulfoxide; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; In methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Sharpless dihydroxylation / 5: Swern oxidation / 6: Hosomi-Sakurai allylation;
DOI:10.1021/ol102856j