2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Base Information

Chemical Name:2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
CAS No.:1038915-58-0
Molecular Formula:C₁₉H₂₀N₄O
Molecular Weight:320.394
Hs Code.:

Synonyms:2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Suppliers and Price of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ent-Niraparib
500mg
$ 2230.00

Crysdot
(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 97%
1g
$ 3294.00

Crysdot
(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 97%
5g
$ 7064.00

ChemScene
NiraparibR-enantiomer 99.50%
50mg
$ 990.00

ChemScene
NiraparibR-enantiomer 99.50%
10mg
$ 380.00

ChemScene
NiraparibR-enantiomer 99.50%
5mg
$ 220.00

Alichem
(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
100g
$ 35175.00

Alichem
(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
5g
$ 9849.00

Alichem
(R)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
1g
$ 5159.00

Total 11 raw suppliers

Chemical Property of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Chemical Property:

Boiling Point:463.6±45.0 °C(Predicted)
Density:1.34±0.1 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

ent-Niraparib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses ent-Niraparib is an isomer of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Technology Process of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

There total 7 articles about 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

: niraparib L-tartaric acid

: 1038915-58-0
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Guidance literature:: With sodium hydroxide; In water; ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 1038915-56-8
racemic 3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidinium chloride

: 1038915-60-4
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine

: 1038915-58-0
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Guidance literature:: With diethylamine; In isopropyl alcohol; at 35 ℃; under 75007.5 Torr; Purification / work up; Resolution of racemate;

Reference yield:

: 1038915-90-0
methyl 2-{4-[1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylate

: 1038915-58-0
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: formamide; sodium methylate / N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C

2: trifluoroacetic acid / dichloromethane / 24 h

3: ethanol / 0.5 h / Reflux

4: sodium hydroxide / water; ethyl acetate / 3 h / 20 °C

With sodium methylate; formamide; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;