1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

Base Information

Chemical Name:1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone
CAS No.:1047670-30-3
Molecular Formula:C₂₄H₂₃Cl₃N₂O
Molecular Weight:461.818
Hs Code.:

Synonyms:1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

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Technology Process of 1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

There total 5 articles about 1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1047670-24-5
N-methoxy-N-methyl-1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 1047670-30-3
1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 1047670-24-5
N-methoxy-N-methyl-1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 2550-36-9
Cyclohexylmethyl bromide

: 1047670-30-3
1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

Guidance literature:: Cyclohexylmethyl bromide; With magnesium; In tetrahydrofuran; at 0 ℃;

N-methoxy-N-methyl-1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1047670-30-3
1-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl]-2-cyclohexylethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium / ethanol / 18 h / 20 °C

2.1: ethanol / 16 h / Reflux

3.1: trimethylaluminum / hexane; dichloromethane / 1.42 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

With trimethylaluminum; sodium; In tetrahydrofuran; ethanol; hexane; dichloromethane; 1.1: |Claisen Condensation / 4.1: |Grignard Reaction;
DOI:10.1016/j.ejmech.2012.12.056