2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

Base Information

Chemical Name:2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine
CAS No.:879486-04-1
Molecular Formula:C₂₄H₃₀BN₃O₂
Molecular Weight:403.332
Hs Code.:

Synonyms:2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

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Chemical Property of 2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

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Technology Process of 2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

There total 2 articles about 2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 879485-69-5
2-[4-(3-bromo-phenyl)-2-isopropyl-1H-imidazol-5-yl]-6-methyl-pyridine

: 73183-34-3
bis(pinacol)diborane

: 879486-04-1
2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 90 ℃; for 18h;

Reference yield:

: 879485-68-4
1-(3-bromo-phenyl)-2-(6-methyl-pyridin-2-yl)ethanone

: 879486-04-1
2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; tert.-butylnitrite / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / Heating / reflux

1.3: 1 h / 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 90 °C

With hydrogenchloride; tert.-butylnitrite; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 34.0%

: 879486-59-6
N-(4-bromo-3-fluoro-phenyl)-methanesulfonamide

: 879486-04-1
2-{2-isopropyl-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-4-yl}-6-methylpyridine

: N-{2-Fluoro-3'-[2-isopropyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]-1,1'-biphenyl-4-yl}methanesulfonamide

Guidance literature:: With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; for 6h; Heating / reflux;