(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Base Information

Chemical Name:(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane
CAS No.:1403355-68-9
Molecular Formula:C₂₆H₄₂O₅Si
Molecular Weight:462.702
Hs Code.:

Synonyms:(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

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Chemical Property of (8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

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Technology Process of (8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

There total 7 articles about (8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1403355-66-7
(8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

: 1403355-68-9
(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Guidance literature:: With methanol; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201200294

Reference yield:

: 912469-49-9
3-methoxy-2-((trimethylsilyl)ethynyl)benzaldehyde

: 1403355-68-9
(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 24 h / 0 °C / Inert atmosphere

3.1: methanol; potassium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; methanol; boron trifluoride diethyl etherate; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201200294

Reference yield:

: 77120-79-7
1-<(2-methoxyethoxy)methoxy>-2-propene

: 1403355-68-9
(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / -78 °C / Inert atmosphere

2.2: 12 h / -78 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 24 h / 0 °C / Inert atmosphere

4.1: methanol; potassium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; methanol; boron trifluoride diethyl etherate; sec.-butyllithium; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201200294