(8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Base Information

• Chemical Name: (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane
• CAS No.: 1403355-66-7
• Molecular Formula: C₂₉H₅₀O₅Si₂
• Molecular Weight: 534.884
• Mol file: 1403355-66-7.mol

Synonyms:(8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Chemical Property of (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane

There total 6 articles about (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1R,2R)-2-[(2-methoxyethoxy)methoxy]-1-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}but-3-en-1-ol (1403355-65-6) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane (1403355-66-7)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201200294

Reference yield:

3-methoxy-2-((trimethylsilyl)ethynyl)benzaldehyde (912469-49-9) → (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane (1403355-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 24 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201200294

Reference yield:

C27H47BO3 → (8R,9R)-11,11-diisopropyl-9-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane (1403355-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 24 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201200294

upstream raw materials:

3-methoxy-2-((trimethylsilyl)ethynyl)benzaldehyde

(1R,2R)-2-[(2-methoxyethoxy)methoxy]-1-{3-methoxy-2-[(trimethylsilyl)ethynyl]phenyl}but-3-en-1-ol

triisopropylsilyl trifluoromethanesulfonate

1-<(2-methoxyethoxy)methoxy>-2-propene

Downstream raw materials:

(8R,9R)-9-(2-ethynyl-3-methoxyphenyl)-11,11-diisopropyl-12-methyl-8-vinyl-2,5,7,10-tetraoxa-11-silatridecane