N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

Base Information

Chemical Name:N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide
CAS No.:1620482-65-6
Molecular Formula:C₂₈H₃₃N₇O₂
Molecular Weight:499.616
Hs Code.:

Synonyms:N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

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Technology Process of N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

There total 3 articles about N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1620482-54-3
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-2-propyn-1-amine

: 142-61-0
Hexanoyl chloride

: 1620482-65-6
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-11-5
{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methanol

: 1620482-65-6
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; triethylamine / ethyl acetate; dimethyl sulfoxide / 0.33 h / 0 - 20 °C / Inert atmosphere

2: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 20 °C / Inert atmosphere

With pyridine; trimethylsilylazide; sulfur trioxide pyridine complex; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-12-6
4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzaldehyde

: 1620482-65-6
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-N-(2-propyn-1-yl)hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 20 °C / Inert atmosphere

With pyridine; trimethylsilylazide; In methanol; dichloromethane;
DOI:10.1021/ja505517t