2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Base Information

Chemical Name:2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide
CAS No.:1268634-80-5
Molecular Formula:C₂₄H₁₉ClF₆N₆O₅
Molecular Weight:620.895
Hs Code.:

2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Synonyms:2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Suppliers and Price of 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

There total 12 articles about 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268636-01-6
N-{(2R)-1-amino-1-{[(isobutoxycarbonyl)oxy]imino}-2-[3-(trifluoromethyl)phenyl]propan-2-yl}-2-{3-(4-chloro-phenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

: 1268634-80-5
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Guidance literature:: With sodium t-butanolate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1228650-25-6
5-(4-chlorophenyl)-4-[⁽²⁸⁾-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1268634-80-5
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

2.1: chiral selector poly(N-methacryloyl-L-isoleucine-3-pentylamide)-based silica gel column / ethyl acetate; 2-Methylpentane / 24 °C / Resolution of racemate

3.1: water; lithium hydroxide / methanol / 1 h / 20 °C

3.2: pH 1 - 2

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h / 20 °C

4.2: 1 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

5.2: 0.33 h / 20 °C

6.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 20 °C

7.1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 75 °C

8.1: pyridine / N,N-dimethyl-formamide / 0 °C

9.1: sodium t-butanolate / N,N-dimethyl-formamide / 20 °C

With pyridine; hydroxylamine hydrochloride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; potassium iodide; lithium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; 2-Methylpentane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1245940-77-5
(2R)-2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanoic acid

: 1268634-80-5
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-[3-(trifluoro-methyl)phenyl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

1.2: 0.33 h / 20 °C

2.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 75 °C

4.1: pyridine / N,N-dimethyl-formamide / 0 °C

5.1: sodium t-butanolate / N,N-dimethyl-formamide / 20 °C

With pyridine; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; sodium t-butanolate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;