Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Base Information

• Chemical Name: Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
• CAS No.: 161860-50-0
• Molecular Formula: C₁₉H₁₈F₃N₄O₇P
• Molecular Weight: 502.343
• Mol file: 161860-50-0.mol

Synonyms:Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Chemical Property of Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester

There total 3 articles about Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione (161860-47-5) → Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (161860-50-0)

Guidance literature:

With triethyl phosphate; trichlorophosphate; at 4 ℃; for 24h;

DOI:10.1080/07328319608002409

Reference yield:

2',3'-Dideoxyuridine (5983-09-5,153547-98-9) → Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (161860-50-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 73 percent / phosphoryl chloride, triethyl phosphate / 24 h / 4 °C

With triethyl phosphate; trichlorophosphate;

DOI:10.1080/07328319608002409

Reference yield:

3-(4-ethenylphenyl)-3-trifluoromethyl-3H-diazirine (88390-09-4) → Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (161860-50-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 73 percent / phosphoryl chloride, triethyl phosphate / 24 h / 4 °C

With triethyl phosphate; trichlorophosphate;

DOI:10.1080/07328319608002409

upstream raw materials:

1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione

3-(4-ethenylphenyl)-3-trifluoromethyl-3H-diazirine

2',3'-Dideoxyuridine