1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione
• CAS No.: 161860-47-5
• Molecular Formula: C₁₉H₁₇F₃N₄O₄
• Molecular Weight: 422.364
• Mol file: 161860-47-5.mol

Synonyms:1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione

Chemical Property of 1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione

There total 1 articles about 1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-ethenylphenyl)-3-trifluoromethyl-3H-diazirine (88390-09-4) + 2',3'-Dideoxyuridine (5983-09-5,153547-98-9) → 1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione (161860-47-5)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1080/07328319608002409

Reference yield: 73.0%

1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione (161860-47-5) → Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester (161860-50-0)

Guidance literature:

With triethyl phosphate; trichlorophosphate; at 4 ℃; for 24h;

DOI:10.1080/07328319608002409

Reference yield:

1-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-1H-pyrimidine-2,4-dione (161860-47-5) → 2',3'-dideoxy-E-5-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]styryl}uridine 5'-diphosphate

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / phosphoryl chloride, triethyl phosphate / 24 h / 4 °C

With triethyl phosphate; trichlorophosphate;

DOI:10.1080/07328319608002409

upstream raw materials:

3-(4-ethenylphenyl)-3-trifluoromethyl-3H-diazirine

2',3'-Dideoxyuridine

Downstream raw materials:

Phosphoric acid mono-[(2S,5R)-5-(2,4-dioxo-5-{(E)-2-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-vinyl}-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester