4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde

Base Information

• Chemical Name: 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde
• CAS No.: 328546-92-5
• Molecular Formula: C₁₈H₁₄N₂O₂
• Molecular Weight: 290.321

Synonyms:4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde

Chemical Property of 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde

There total 3 articles about 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-(iodophenyl)carboxaldehyde (15164-44-0) + 9-ethynyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one (328546-91-4) → 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde (328546-92-5)

Guidance literature:

With copper(l) iodide; tetrakistriphenylphosphine palladium chloride; diethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm030513r

Reference yield:

9-iodo-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one (328546-79-8) → 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde (328546-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / tetrakistriphenylphosphine palladium chloride; CuI; diethylamine / dimethylformamide / 5 h / 20 °C

2: K₂CO₃; methanol / 2.5 h / 20 °C

3: tetrakistriphenylphosphine palladium chloride; CuI; diethylamine / dimethylformamide / 2 h / 20 °C

With methanol; copper(l) iodide; tetrakistriphenylphosphine palladium chloride; potassium carbonate; diethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm030513r

Reference yield:

9-trimethylsilanylethynyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one (328546-90-3) → 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde (328546-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃; methanol / 2.5 h / 20 °C

2: tetrakistriphenylphosphine palladium chloride; CuI; diethylamine / dimethylformamide / 2 h / 20 °C

With methanol; copper(l) iodide; tetrakistriphenylphosphine palladium chloride; potassium carbonate; diethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm030513r

upstream raw materials:

p-(iodophenyl)carboxaldehyde

9-ethynyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one

9-iodo-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one

9-trimethylsilanylethynyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one

Downstream raw materials:

4-(1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-6-yl)-benzaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 328546-92-5 4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylethynyl)-benzaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send