9-Iodo-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one

Base Information

• Chemical Name: 9-Iodo-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one
• CAS No.: 328546-79-8
• Molecular Formula: C9H9 I N2 O
• Molecular Weight: 288.09
• Hs Code.: 2933990090
• European Community (EC) Number: 849-242-6
• DSSTox Substance ID: DTXSID80465552
• Wikidata: Q82291587
• Mol file: 328546-79-8.mol

Synonyms:328546-79-8;9-IODO-1,2,3,4-TETRAHYDRO-5H-1,4-BENZODIAZEPIN-5-ONE;9-iodo-1,2,3,4-tetrahydro-1,4-benzodiazepin-5-one;9-IODO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-5(2H)-ONE;SCHEMBL6198768;DTXSID80465552;9-IODO-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-5-ONE;AB44268;EN300-7542475

Chemical Property of 9-Iodo-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one

Chemical Property:

• Melting Point: 182-184 °C
• Boiling Point: 497.9±45.0 °C(Predicted)
• PKA: 13.72±0.20(Predicted)
• PSA: 41.13000
• Density: 1.749±0.06 g/cm3(Predicted)
• LogP: 1.91330
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 287.97596
• Heavy Atom Count: 13
• Complexity: 210

Purity/Quality:

98%min ^*data from raw suppliers

9-IODO-1,2,3,4-TETRAHYDRO-5H-1,4-BENZODIAZEPIN-5-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC(=O)C2=C(N1)C(=CC=C2)I

Technology Process of 9-Iodo-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one

There total 1 articles about 9-Iodo-1,2,3,4-tetrahydro-5H-1,4-benzodiazepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-iodo-2,3-dihydro-1H-quinolin-1-one (328546-78-7) → 9-iodo-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one (328546-79-8)

Guidance literature:

With sodium azide; methanesulfonic acid; at 20 ℃; for 0.5h;

DOI:10.1021/jm030513r

Reference yield: 78.0%

phenylacetylene (536-74-3) + 9-iodo-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one (328546-79-8) → 9-phenylethynyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one

Guidance literature:

With copper(l) iodide; tetrakistriphenylphosphine palladium chloride; diethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm030513r

Reference yield:

1-ethynyl-4-fluorobenzene (766-98-3) + 9-iodo-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one (328546-79-8) → s-9-(4-Fluorophenylethynyl)-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one (328546-84-5)

Guidance literature:

With copper(l) iodide; tetrakistriphenylphosphine palladium chloride; diethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm030513r

upstream raw materials:

8-iodo-2,3-dihydro-1H-quinolin-1-one

Downstream raw materials:

s-9-(4-Fluorophenylethynyl)-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one

9-(4-chloro-phenylethynyl)-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one

r-9-(4-Phenylbutynyl)-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one

3-(1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-6-yl)-benzaldehyde