Technology Process of (Z)-2-(1-ethoxyethoxy)-N'-hydroxy-3-methoxy-3-(4-morpholinophenyl)propanimidamide
There total 6 articles about (Z)-2-(1-ethoxyethoxy)-N'-hydroxy-3-methoxy-3-(4-morpholinophenyl)propanimidamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; sodium hydrogencarbonate;
In
methanol;
at 60 - 75 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.83 h / Inert atmosphere; Cooling with ice
1.2: 16 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; toluene; hexanes / 1.08 h / -78 °C
2.2: 0.5 h / 20 °C
3.1: zinc(II) iodide / diethyl ether / 15.5 h / 20 °C
4.1: pyridinium p-toluenesulfonate / dichloromethane / 40 h / 20 °C / Inert atmosphere
5.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 60 - 75 °C / Inert atmosphere
With
4-methyl-morpholine; hydroxylamine hydrochloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; zinc(II) iodide; isobutyl chloroformate;
In
methanol; hexanes; diethyl ether; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / 1,4-dioxane / 18 h
1.2: pH 2
2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.83 h / Inert atmosphere; Cooling with ice
2.2: 16 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; toluene; hexanes / 1.08 h / -78 °C
3.2: 0.5 h / 20 °C
4.1: zinc(II) iodide / diethyl ether / 15.5 h / 20 °C
5.1: pyridinium p-toluenesulfonate / dichloromethane / 40 h / 20 °C / Inert atmosphere
6.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 60 - 75 °C / Inert atmosphere
With
4-methyl-morpholine; hydroxylamine hydrochloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium hydroxide; zinc(II) iodide; isobutyl chloroformate;
In
1,4-dioxane; methanol; hexanes; diethyl ether; dichloromethane; toluene;
