Technology Process of (1R,4R)-4-(benzyloxymethyl)cyclopent-2-enyl benzoate
There total 7 articles about (1R,4R)-4-(benzyloxymethyl)cyclopent-2-enyl benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
diethyl ether;
at 0 ℃;
for 0.5h;
Inert atmosphere;
(1S)-cis-4-Benzyloxymethylcyclopent-2-en-1-ol;
With
benzoic acid;
In
diethyl ether;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.201001473
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / Reflux
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; potassium tert-butylate; triphenylphosphine;
In
diethyl ether; N,N-dimethyl-formamide;
2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1002/ejoc.201001473
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere
2.1: L-diisopinocampheylborane / tetrahydrofuran / -78 - 0 °C / Inert atmosphere
2.2: 4 h / 0 °C
3.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C
4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.2: oxone / 6 h / 0 °C
5.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / Reflux
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 0.5 h / 0 °C / Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; potassium tert-butylate; sodium hydride; triethylamine; 9-bora-bicyclo[3.3.1]nonane; triphenylphosphine; L-diisopinocampheylborane;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
2.1: Hydroboration reaction / 4.1: Hydroboration reaction / 6.1: Mitsunobu reaction / 6.2: Mitsunobu reaction;
DOI:10.1002/ejoc.201001473
