6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Base Information

Chemical Name:6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione
CAS No.:133549-97-0
Molecular Formula:C₂₉H₂₆N₄O₃
Molecular Weight:478.55
Hs Code.:

Synonyms:6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

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Chemical Property of 6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

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Technology Process of 6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

There total 3 articles about 6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 133549-68-5
6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

: 532-27-4,108321-66-0,164322-25-2
1-chloroacetophenone

: 133549-97-0
6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 30 - 35 ℃; for 24h;
DOI:10.1021/jm00109a028

Reference yield:

: 7242-92-4
exo-2-aminonorbornane

: 133549-97-0
6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) NaOC₂H₅ / 1.) C₂H₅OH, RT, 24 h, 2.) C₂H₅OH, reflux, 1 h

2: 73 percent / glacial acetic acid / Heating

3: 87 percent / K₂CO₃ / dimethylformamide / 24 h / 30 - 35 °C

With sodium ethanolate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00109a028

Reference yield:

: 133549-47-0
1-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

: 133549-97-0
6-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-4-(2-oxo-2-phenyl-ethyl)-2-phenyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / glacial acetic acid / Heating

2: 87 percent / K₂CO₃ / dimethylformamide / 24 h / 30 - 35 °C

With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00109a028