methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate

Base Information

• Chemical Name: methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate
• CAS No.: 915777-58-1
• Molecular Formula: C₂₃H₃₀BrNO₄SSi
• Molecular Weight: 524.551
• Mol file: 915777-58-1.mol

Synonyms:methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate

Chemical Property of methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate

There total 3 articles about methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 2-(phenyl(2-(trimethylsilyl)ethylsulfonamido)methyl)acrylate (816457-61-1) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate (915777-58-1)

Guidance literature:

With potassium carbonate; In acetonitrile; for 6h; Heating;

DOI:10.1002/ejoc.200600680

Reference yield:

2-(trimethylsilyl)ethanesulfonamide (125486-96-6) → methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate (915777-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: DABCO

2: 80 percent / K₂CO₃ / acetonitrile / 6 h / Heating

With potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; 1: aza-Baylis-Hillman reaction;

DOI:10.1016/j.tet.2006.08.009

Reference yield:

benzaldehyde (100-52-7) → methyl 2-((N-2-bromobenzyl-2-(trimethylsilyl)ethan-3-ylsulfonamido)(phenyl)methyl)acrylate (915777-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: DABCO

2: 80 percent / K₂CO₃ / acetonitrile / 6 h / Heating

With potassium carbonate; 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; 1: aza-Baylis-Hillman reaction;

DOI:10.1016/j.tet.2006.08.009

upstream raw materials:

methyl 2-(phenyl(2-(trimethylsilyl)ethylsulfonamido)methyl)acrylate

1-Bromo-2-bromomethyl-benzene

2-(trimethylsilyl)ethanesulfonamide

benzaldehyde

Downstream raw materials:

3-phenyl-2-(2-(trimethylsilanyl)ethylsulfonyl)-2,3-dihydro-1H-benzo[c]azepine-4-carboxylic acid methyl ester