(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Base Information

Chemical Name:(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide
CAS No.:144765-79-7
Molecular Formula:C₁₉H₂₉ClN₂O₆S
Molecular Weight:448.968
Hs Code.:

Synonyms:(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Suppliers and Price of (S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

There total 5 articles about (S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 124-63-0
methanesulfonyl chloride

: 144765-77-5
(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-hydroxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

: 144765-79-7
(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1248/cpb.40.1793

Reference yield:

: 101536-78-1
3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoic acid

: 144765-79-7
(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 0.33 h / Ambient temperature

3: 88 percent / 1 N HCl / 1 h / Ambient temperature

4: 28 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

With hydrogenchloride; triethylamine; In dichloromethane;
DOI:10.1248/cpb.40.1793

Reference yield:

: (S)-2-aminomethyl-1-(3'-tetrahydropyranyloxypropyl)pyrrolidine

: 144765-79-7
(S)-(-)-5-chloro-3-ethyl-N-<<1-(3'-methanesulfonyloxypropyl)-2-pyrrolidinyl>methyl>-6-methoxysalicylamide

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 0.33 h / Ambient temperature

2: 88 percent / 1 N HCl / 1 h / Ambient temperature

3: 28 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

With hydrogenchloride; triethylamine; In dichloromethane;
DOI:10.1248/cpb.40.1793