2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

Base Information

Chemical Name:2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide
CAS No.:863330-85-2
Molecular Formula:C₂₁H₂₆N₂O₂S
Molecular Weight:370.516
Hs Code.:

Synonyms:2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

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Chemical Property of 2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

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Technology Process of 2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

There total 6 articles about 2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 863330-84-1
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-2-pyrrolinecarboxamide

: 863330-85-2
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

Guidance literature:: With sodium cyanoborohydride; In acetonitrile; at 20 ℃; for 2h;
DOI:10.3390/10010295

Reference yield:

: 3179-09-7,55446-68-9
(E)-1-methoxy-3-(2-nitrovinyl)benzene

: 863330-85-2
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / N-isopropylcyclohexylamine / CH₂Cl₂ / 1 h / 20 °C

2: 45 percent / acetic acid; Zn; HCL / 20 °C

3: 20 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; 4-N,N-dimethylaminopyridine / tetrahydrofuran / 24 h

4: 97 percent / HF / acetonitrile / Heating

5: 80 percent / sodium cyanoborohydride / acetonitrile / 2 h / 20 °C

With hydrogenchloride; dmap; N-cyclohexylisopropylamine; hydrogen fluoride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Michael addition;
DOI:10.3390/10010295

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 863330-85-2
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-methyl-2-pyrrolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / glacial acetic acid; ammonium acetate / 1 h / Heating

2: 90 percent / N-isopropylcyclohexylamine / CH₂Cl₂ / 1 h / 20 °C

3: 45 percent / acetic acid; Zn; HCL / 20 °C

4: 20 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; 4-N,N-dimethylaminopyridine / tetrahydrofuran / 24 h

5: 97 percent / HF / acetonitrile / Heating

6: 80 percent / sodium cyanoborohydride / acetonitrile / 2 h / 20 °C

With ammonium acetate; hydrogenchloride; dmap; N-cyclohexylisopropylamine; hydrogen fluoride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane; acetonitrile; 2: Michael addition;
DOI:10.3390/10010295