4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

Base Information

Chemical Name:4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde
CAS No.:1440528-85-7
Molecular Formula:C₅₁H₆₇N₅OS₂
Molecular Weight:830.258
Hs Code.:

Synonyms:4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

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Chemical Property of 4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

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Technology Process of 4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

There total 8 articles about 4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1440528-42-6
5,5’-((4-bromophenyl)azanediyl)bis(1,3-dihexyl-1H-benzo[d]imidazole-2(3H)-thione)

: 87199-17-5
4-formylphenylboronic acid,

: 1440528-85-7
4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; for 20h; Reflux;
DOI:10.1021/ol4001685

Reference yield:

: 10602-01-4
p-bromobenzaldehyde 1,3-dioxolane

: 1440528-85-7
4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 20 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; water;
DOI:10.1021/ol4001685

Reference yield:

: 615-16-7
1,3-dihydro-2H-benzimidazol-2-one

: 1440528-85-7
4’-(bis(1,3-dihexyl-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)-[1,1’-biphenyl]-4-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 10 h / 60 °C

2: sulfuric acid; iodine; sodium periodate / water; acetic acid / 8 h / 40 °C

3: copper(l) iodide; [2,2]bipyridinyl; potassium tert-butylate / toluene / 14 h / 140 °C / Sealed tube

4: Lawessons reagent / toluene / 12 h / 110 °C

5: N-Bromosuccinimide / tetrachloromethane / 4 h / 20 - 75 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 20 h / Reflux

With Lawessons reagent; [2,2]bipyridinyl; sodium periodate; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium tert-butylate; tetrabutylammomium bromide; iodine; potassium carbonate; sodium hydroxide; In tetrahydrofuran; tetrachloromethane; water; acetic acid; toluene;
DOI:10.1021/ol4001685