2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS No.:1269117-06-7
Molecular Formula:C₂₈H₃₅N₅O₆
Molecular Weight:537.616
Hs Code.:

2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Synonyms:2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of 2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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Technology Process of 2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

There total 8 articles about 2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1269118-91-3
2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

: 70-11-1
α-bromoacetophenone

: 1269117-06-7
2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: 2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; With potassium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; for 0.166667h; Cooling with ice;

With lithium bromide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; for 0.333333h; Cooling with ice;

α-bromoacetophenone; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 80 - 90 ℃; for 18.5h;

Reference yield:

: 1269118-44-6
C₇H₆Cl₂N₂O₂

: 1269117-06-7
2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 35 °C / Cooling with ice

2.1: triethylamine / 1 h / 35 °C / Cooling with ice

3.1: triethylamine / tetrahydrofuran / 19.5 h / 10 - 35 °C

4.1: sodium ethanolate / ethanol / 0.25 h / 10 - 35 °C

4.2: 0.5 h / 0 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4.5 h / 35 °C / Cooling with ice

6.1: sodium acetate; acetic acid / 1 h / Reflux

7.1: sodium hydroxide; water / ethanol / 72 h / 10 - 60 °C

7.2: 0.17 h / 0 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 35 °C / Cooling with ice

9.1: potassium carbonate / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.17 h / Cooling with ice

9.2: 0.33 h / Cooling with ice

9.3: 18.5 h / 80 - 90 °C

With oxalyl dichloride; water; sodium ethanolate; sodium acetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 3709-98-6
2-ethylpyrimidine-4,6-diol

: 1269117-06-7
2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: trichlorophosphate / 17 h / 10 °C / Reflux

2.1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol / 0.5 h / 10 - 35 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 35 °C / Cooling with ice

4.1: triethylamine / 1 h / 35 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 19.5 h / 10 - 35 °C

6.1: sodium ethanolate / ethanol / 0.25 h / 10 - 35 °C

6.2: 0.5 h / 0 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4.5 h / 35 °C / Cooling with ice

8.1: sodium acetate; acetic acid / 1 h / Reflux

9.1: sodium hydroxide; water / ethanol / 72 h / 10 - 60 °C

9.2: 0.17 h / 0 °C

10.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 35 °C / Cooling with ice

11.1: potassium carbonate / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.17 h / Cooling with ice

11.2: 0.33 h / Cooling with ice

11.3: 18.5 h / 80 - 90 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; water; sodium ethanolate; sodium acetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;