p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

Base Information

Chemical Name:p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate
CAS No.:79760-02-4
Molecular Formula:C₂₃H₃₄N₂O₇S₃Si
Molecular Weight:574.816
Hs Code.:

Synonyms:p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

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Chemical Property of p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

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Technology Process of p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

There total 8 articles about p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 83654-96-0
p-nitrobenzyl glyoxylate monohydrate

: 79760-00-2,79760-01-3
4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-azetidinone

: 79760-02-4
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

Guidance literature:: In benzene; for 2h; Heating;
DOI:10.1248/cpb.29.1854

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 79760-02-4
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / imidazole / CH₂Cl₂ / Ambient temperature

2: 1.) sodium isopropoxide / 1.) 5 min, isopropanol, 0 deg C, 2.) THF, 0 deg C, 45 min

3: 92 percent / benzene / 2 h / Heating

With 1H-imidazole; sodium isopropylate; In dichloromethane; benzene;
DOI:10.1248/cpb.29.1854

Reference yield:

: 79759-95-8,125606-62-4,125606-68-0,137623-35-9,137623-36-0,138513-11-8
(3S*,4R*)-N-(tert-butyldimethylsilyl)-3-ethyl-4-(phenylthio)azetidin-2-one

: 79760-02-4
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-3-ethyl-2-oxo-1-azetidinyl>-2-hyxdroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / ethyl acetate; acetic acid / 1 h / Ambient temperature

2: tetrabutylammonium fluoride, acetic acid / tetrahydrofuran / 1.5 h / 0 °C

3: 1.) sodium isopropoxide / 1.) 5 min, isopropanol, 0 deg C, 2.) THF, 0 deg C, 45 min

4: 92 percent / benzene / 2 h / Heating

With tetrabutyl ammonium fluoride; sodium isopropylate; acetic acid; In tetrahydrofuran; acetic acid; ethyl acetate; benzene;
DOI:10.1248/cpb.29.1854