1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine
CAS No.:1312019-10-5
Molecular Formula:C₂₇H₂₆N₂O₅S₂
Molecular Weight:522.646
Hs Code.:

Synonyms:1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

There total 8 articles about 1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1312019-09-2
toluene-4-sulfonic acid 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-pyran-yl)-vinyl ester

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1312019-10-5
1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 100 ℃; for 4h; Microwave irradiation;

Reference yield:

: 86266-57-1
2-(tetrahydropyran-2-yl)acetaldehyde

: 1312019-10-5
1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

1.2: 1 h / -78 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

3.1: Daicel IA-H / isopropyl alcohol; hexanes / 25 °C / Resolution of racemate

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.2: 1.5 h / -78 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 4 h / 100 °C / Microwave irradiation

With sodium carbonate; Dess-Martin periodane; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 38786-78-6
(+/-)-ethyl tetrahydro-2H-pyran-2-acetate

: 1312019-10-5
1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-2-yl)-vinyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

3.2: 1 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

5.1: Daicel IA-H / isopropyl alcohol; hexanes / 25 °C / Resolution of racemate

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 1.5 h / -78 °C

7.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 4 h / 100 °C / Microwave irradiation

With lithium aluminium tetrahydride; sodium carbonate; Dess-Martin periodane; pyridinium chlorochromate; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water; isopropyl alcohol;