86266-57-1Relevant academic research and scientific papers
AZAINDOLE GLUCOKINASE ACTIVATORS
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Page/Page column 49, (2011/06/26)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
Organocatalytic synthesis of an alkyltetrahydropyran
Díez,Nú?ez,Benéitez,Moro,Marcos,Basabe,Broughton,Urones
scheme or table, p. 390 - 394 (2009/08/07)
The first synthesis of an alkyltetrahydropyran using a diarylprolinol organocatalyst is described. Georg Thieme Verlag Stuttgart.
PURINE DERIVATIVES AS IMMUNOMODULATORS
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Page/Page column 90, (2008/12/08)
The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants
A novel synthesis of the north west portion of Lasonolide A - An anticancer macrolide using Claisen rearrangement
Kar, Paramita,Rao,Nagaiah,Gurjar
, p. 52 - 54 (2007/10/03)
A simplified analogue of Lasonolide A (C23-C35 side chain) was synthesized using Fujisawa's stereoselective variant of the Ireland Claisen ester rearrangement.
Obtention d'aldehydes γ-fonctionnels au cours de la thermolyse du percarbonate de O,O-t-butyle et O-vinyle en solution
Filliatre, Claude,Villenave, Jean-Jacques,Jaouhari, Rabih,Baratchart, Michel
, p. 352 - 356 (2007/10/02)
Owing to its peroxyester group, O,O-tert-butyl and O-vinyle peroxycarbonate may act as a free radical initiator in solution, but also, due to the presence of the vinylic insaturation, as a substrate for free radical addition reactions. - In such solvents as cumene which give free radicals unable to add to the double bond, the peroxycarbonate merely behaves as a vinyloxy radicals generator.It is thus possible to observe these radicals reacting either as formylmethyl radicals or as acetyl radicals. - In solvents such as cyclohexane which give free radicals able to add to the double bond, the reaction results in the substitution of formylmethyl groups to labile hydrogens of the solvent. - By applying the reaction to such compounds as ketones, ethers, acids and their derivatives, we could obtain γ-functional aldehydes (γ-ketoaldehydes, γ-oxaaldehydes and derivatives of succinaldehydic acids).These products are often difficult to prepare by other routes and until now only some of them have been described.
