ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Base Information

Chemical Name:ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate
CAS No.:1132814-74-4
Molecular Formula:C₁₉H₂₁F₄NO₄
Molecular Weight:403.374
Hs Code.:

Synonyms:ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

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Chemical Property of ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

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Technology Process of ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

There total 7 articles about ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1132814-73-3
1-amino-1-(2-hydroxypropan-1-yl)cyclobutane

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 122-51-0
orthoformic acid triethyl ester

: 1132814-74-4
ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Guidance literature:: ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate; orthoformic acid triethyl ester; With acetic anhydride; at 120 ℃; for 3h;

1-amino-1-(2-hydroxypropan-1-yl)cyclobutane; In toluene; at 0 - 20 ℃; for 2h;

Reference yield:

: 1132814-73-3
1-amino-1-(2-hydroxypropan-1-yl)cyclobutane

: 94714-58-6
ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

: 1132814-74-4
ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Guidance literature:: In toluene; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.12.046

Reference yield:

: 1132814-70-0
2-(1-(benzoylamino)cyclobutyl)acetaldehyde

: 1132814-74-4
ethyl 3-{[1-(2-hydroxypropan-1-yl)cyclobutyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 5 h / 0 - 20 °C

1.2: 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Reflux

2.2: Cooling with ice

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 10 h / 20 °C / 5 kgf/cm²

4.1: toluene / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmc.2011.12.046