(S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

Base Information

Chemical Name:(S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone
CAS No.:148357-98-6
Molecular Formula:C₂₀H₃₄N₂O₇
Molecular Weight:414.499
Hs Code.:

Synonyms:(S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

Suppliers and Price of (S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

Chemical Property:

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Technology Process of (S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

There total 1 articles about (S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 148357-98-6
(S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen azide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; benzene / a) -10 deg C, 30 min, b) 0 deg C, 2 h, c) RT, overnight

2: hydrogen / palladium on activated charcoal / ethanol / 6 h / 2068.6 Torr

3: dmap / 1.) CH₃CN, 0 deg C, 1 h, 2.) CH₃CN, RT, 48 h

With dmap; hydrogen azide; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; benzene;
DOI:10.1016/S0957-4166(00)86019-X

Reference yield:

: 148357-98-6
(S)-5-<(di-tert-butoxycarbonyl)aminomethyl>-1-tert-butoxycarbonyl-2-pyrrolidone

: 156604-31-8
(2S)-N⁴-benzyloxycarbonyl-N¹,N²-di-tert-butoxycarbonyl-1,2,4-triaminobutane

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / aq. LiOH / tetrahydrofuran

2: 80 percent / MeONa / methanol / 6 h / Heating

3: Et₃N / tetrahydrofuran / 0.5 h

4: NaN₃ / tetrahydrofuran / 0.5 h / 0 °C

5: benzene / 1 h / 70 °C

6: p-TsOH / benzene / Ambient temperature

With lithium hydroxide; sodium azide; sodium methylate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; benzene;
DOI:10.1016/S0957-4166(00)86240-0