prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Base Information

Chemical Name:prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate
CAS No.:1455036-73-3
Molecular Formula:C₂₉H₃₀N₄O₃
Molecular Weight:482.582
Hs Code.:

Synonyms:prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

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Chemical Property of prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

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Technology Process of prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

There total 9 articles about prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 57933-83-2
Isopropenyl chloroformate

: 1455036-18-6
3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine

: 1455036-73-3
prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1001756-21-3
4-amino-6-chloropyridine-3-carboxaldehyde

: 1455036-73-3
prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 64 h / 185 °C / Inert atmosphere

5: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1455035-96-7
7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate

: 1455036-73-3
prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 64 h / 185 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b00067