Technology Process of N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3,5-bis(carbomethoxy)pyridinium p-toluenesulfonate
There total 15 articles about N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3,5-bis(carbomethoxy)pyridinium p-toluenesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 90 percent / LiOH / methanol / 2 h
2: 89 percent / diethyl ether; tetrahydrofuran / 3 h
3: 95 percent / Hydrazine Hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 100 - 200 °C
4: 98.5 percent / Imidazole / dimethylformamide / 168 h
5: tert-Butylhypochlorite, Triethylamine / CH2Cl2 / 1 h / -78 °C
6: 74 percent / methanol / 120 h
7: 90 percent / ethyl acetate / 4 h / Ambient temperature
8: 91 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C
9: γ-Collidine / benzene / 1 h / 25 °C
10: benzene
With
1H-imidazole; 2,4,6-trimethyl-pyridine; potassium hydroxide; lithium hydroxide; 18-crown-6 ether; tert-butylhypochlorite; hydrazine hydrate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; diethylene glycol; benzene;
DOI:10.1021/jo00329a029
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / Mercuric acetate / 69 h / 25 °C
2: 70 percent / Trifluoroacetic acid / CH2Cl2 / 2.25 h / 15 - 18 °C
3: 67 percent / ZnCl2 / 72 h / 105 °C
4: γ-Collidine / benzene / 1 h / 25 °C
5: benzene
With
2,4,6-trimethyl-pyridine; mercury(II) diacetate; trifluoroacetic acid; zinc(II) chloride;
In
dichloromethane; benzene;
DOI:10.1021/jo00329a029
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / Hydrazine Hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 100 - 200 °C
2: 98.5 percent / Imidazole / dimethylformamide / 168 h
3: tert-Butylhypochlorite, Triethylamine / CH2Cl2 / 1 h / -78 °C
4: 74 percent / methanol / 120 h
5: 90 percent / ethyl acetate / 4 h / Ambient temperature
6: 91 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C
7: γ-Collidine / benzene / 1 h / 25 °C
8: benzene
With
1H-imidazole; 2,4,6-trimethyl-pyridine; potassium hydroxide; 18-crown-6 ether; tert-butylhypochlorite; hydrazine hydrate; triethylamine;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; diethylene glycol; benzene;
DOI:10.1021/jo00329a029
