3-(p-vinylphenyl)-3-oxopropanenitrile

Base Information

• Chemical Name: 3-(p-vinylphenyl)-3-oxopropanenitrile
• CAS No.: 198213-32-0
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.199
• Mol file: 198213-32-0.mol

Synonyms:3-(p-vinylphenyl)-3-oxopropanenitrile

Chemical Property of 3-(p-vinylphenyl)-3-oxopropanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of 3-(p-vinylphenyl)-3-oxopropanenitrile

There total 1 articles about 3-(p-vinylphenyl)-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-vinylbenzoyl chloride (1565-41-9) + cyanoacetic acid (372-09-8) → 3-(p-vinylphenyl)-3-oxopropanenitrile (198213-32-0)

Guidance literature:

With hydrogenchloride; n-butyllithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h;

DOI:10.1021/ja972158y

Reference yield: 90.0%

3-(p-vinylphenyl)-3-oxopropanenitrile (198213-32-0) → 3-amino-5-(p-vinylphenyl)pyrazole (198213-33-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2.5h; Heating;

DOI:10.1021/ja972158y

Reference yield:

3-(p-vinylphenyl)-3-oxopropanenitrile (198213-32-0) → 3-acetylamino-5-(p-vinylphenyl)pyrazole

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrazine hydrate / ethanol / 2.5 h / Heating

2: 65 percent / Et₃N / dioxane / 12 - 20 °C

With hydrazine hydrate; triethylamine; In 1,4-dioxane; ethanol;

DOI:10.1021/ja972158y

upstream raw materials:

p-vinylbenzoyl chloride

cyanoacetic acid

Downstream raw materials:

3-amino-5-(p-vinylphenyl)pyrazole

Refernces