1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid
CAS No.:1431299-95-4
Molecular Formula:C₂₂H₁₈N₄O₃S
Molecular Weight:418.476
Hs Code.:

Synonyms:1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

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Chemical Property of 1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

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Technology Process of 1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

There total 7 articles about 1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.2%

: 1431300-99-0
ethyl-1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylate

: 1431299-95-4
1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 18 - 25 ℃;

Reference yield:

: 6278-86-0
N₂-(4-bromophenyl)-1,3-benzothiazol-2-amine

: 1431299-95-4
1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; palladium diacetate; tricyclohexylphosphine / 1,4-dioxane / 140 °C / Inert atmosphere

2: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 140 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran; methanol / 18 - 25 °C

With water; potassium acetate; palladium diacetate; potassium carbonate; lithium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2: |Suzuki Coupling;

Reference yield:

: 3697-68-5
ethyl 1-(hydroxymethyl)cyclopropanecarboxylate

: 1431299-95-4
1-(((5-(4-(benzo[d]thiazol-2-ylamino)phenyl)pyrimidin-2-yl)oxy)methyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C

1.2: 18 - 25 °C

2.1: palladium diacetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane; water / 140 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 - 25 °C

With di-isopropyl azodicarboxylate; water; palladium diacetate; potassium carbonate; triphenylphosphine; lithium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2.1: |Suzuki Coupling;