Technology Process of C25H26N2O5S
There total 3 articles about C25H26N2O5S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(2-nitrophenylsulfenyl)-β-(3-hydroxy-4-methoxyphenyl)ethylamine;
With
1,1’-bi-2-naphthol; (R)-3,3′-bis(2,4,6-triisopropylphenyl)-BINOL-phosphoric acid;
In
acetic acid; toluene;
for 0.166667h;
Inert atmosphere;
3-(4-methoxyphenyl)propional;
In
acetic acid; toluene;
at 80 ℃;
Overall yield = 84 %; enantioselective reaction;
Inert atmosphere;
DOI:10.1021/jo501099h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C / Inert atmosphere
2.1: triethylamine; potassium carbonate / chloroform; methanol / 0.08 h / 0 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: (R)-3,3′-bis(2,4,6-triisopropylphenyl)-BINOL-phosphoric acid; 1,1’-bi-2-naphthol / toluene; acetic acid / 0.17 h / Inert atmosphere
3.2: 80 °C / Inert atmosphere
With
1,1’-bi-2-naphthol; palladium 10% on activated carbon; (R)-3,3′-bis(2,4,6-triisopropylphenyl)-BINOL-phosphoric acid; hydrogen; potassium carbonate; triethylamine;
In
methanol; chloroform; acetic acid; toluene;
3.1: |Pictet-Spengler Synthesis;
DOI:10.1021/jo501099h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; potassium carbonate / chloroform; methanol / 0.08 h / 0 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: (R)-3,3′-bis(2,4,6-triisopropylphenyl)-BINOL-phosphoric acid; 1,1’-bi-2-naphthol / toluene; acetic acid / 0.17 h / Inert atmosphere
2.2: 80 °C / Inert atmosphere
With
1,1’-bi-2-naphthol; (R)-3,3′-bis(2,4,6-triisopropylphenyl)-BINOL-phosphoric acid; potassium carbonate; triethylamine;
In
methanol; chloroform; acetic acid; toluene;
2.1: |Pictet-Spengler Synthesis;
DOI:10.1021/jo501099h
