benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate

Base Information

• Chemical Name: benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate
• CAS No.: 1370749-18-0
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 1370749-18-0.mol

Synonyms:benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate

Chemical Property of benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate

There total 3 articles about benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzyl N-[(S)-1-(2-hydroxyphenylcarbamoyl)-2-methylpropyl]carbamate (1370749-27-1) → benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate (1370749-18-0)

Guidance literature:

benzyl N-[(S)-1-(2-hydroxyphenylcarbamoyl)-2-methylpropyl]carbamate; With triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 1h; Molecular sieve; Inert atmosphere;

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃; for 8h; Inert atmosphere; Molecular sieve;

DOI:10.1021/jm201496g

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) → benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate (1370749-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

2.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm201496g

Reference yield:

2-amino-phenol (95-55-6) → benzyl N-[(S)-1-(benzo[d]oxazol-2-yl)-2-methylpropyl]carbamate (1370749-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

2.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm201496g

upstream raw materials:

benzyl N-[(S)-1-(2-hydroxyphenylcarbamoyl)-2-methylpropyl]carbamate

(S)-N-(benzyloxycarbonyl)valine

2-amino-phenol