1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Base Information

Chemical Name:1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine
CAS No.:1402608-06-3
Molecular Formula:C₂₄H₂₄N₄O₂
Molecular Weight:400.48
Hs Code.:

Synonyms:1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

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Chemical Property of 1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

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Technology Process of 1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

There total 3 articles about 1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1402608-94-9
tert-butyl (1-{4-[3-phenyl-6,8-dimethoxyimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 1402608-06-3
1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: tert-butyl (1-{4-[3-phenyl-6,8-dimethoxyimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate; With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃; for 20h;

With sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; pH=> 7; Cooling with ice;

Reference yield:

: 1402608-82-5
tert-butyl (1-{4-[3-phenyl-6,8-dibromoimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 1402608-06-3
1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 13.5 h / 20 - 120 °C / Microwave irradiation

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 h / 20 °C

2.2: pH > 7 / Cooling with ice

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1355999-71-1
tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402608-06-3
1-[4-(6,8-dimethyloxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]-cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / Reflux

2.1: methanol / 13.5 h / 20 - 120 °C / Microwave irradiation

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 h / 20 °C

3.2: pH > 7 / Cooling with ice

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;