tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

Base Information

• Chemical Name: tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate
• CAS No.: 1355999-71-1
• Molecular Formula: C₂₃H₂₆BrNO₃
• Molecular Weight: 444.368
• Mol file: 1355999-71-1.mol

Synonyms:tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

Chemical Property of tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

There total 3 articles about tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate (1032349-98-6) → tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate (1355999-71-1)

Guidance literature:

With pyridinium hydrobromide perbromide; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm201394e

Reference yield:

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate (1032349-96-4) → tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate (1355999-71-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm201394e

Reference yield:

tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate (1032349-97-5) → tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate (1355999-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; In tetrahydrofuran;

DOI:10.1021/jm201394e

upstream raw materials:

tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate

Downstream raw materials:

{1-[4-(7-methoxy-3-phenyl-imidazo[1,2-a]pyrimidin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

{1-[4-(7-hydroxy-3-phenyl-imidazo[1,2-a]pyrimidin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

{1-[4-(8-bromo-6-chloro-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

{1-[4-(6-bromo-8-methyl-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester