3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

Base Information

Chemical Name:3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine
CAS No.:724709-46-0
Molecular Formula:C₄₀H₄₂N₂O₈
Molecular Weight:678.782
Hs Code.:

Synonyms:3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

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Chemical Property of 3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

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Technology Process of 3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

There total 4 articles about 3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 107-30-2
chloromethyl methyl ether

: 724709-45-9
3-N-(benzyloxymethyl)-3'-C-(hydroxymethyl)-5'-O-tritylthymidine

: 724709-46-0
3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

Guidance literature:: 3-N-(benzyloxymethyl)-3'-C-(hydroxymethyl)-5'-O-tritylthymidine; With dibutyldimethoxytin; In 1,4-dioxane; for 5h; Heating;

chloromethyl methyl ether; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Further stages.;
DOI:10.1016/j.tet.2007.06.040

Reference yield:

: 131607-35-7
3'-deoxy-3'-C-methylidene-5'-O-(triphenylmethyl)thymidine

: 724709-46-0
3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / N-methylmorpholine N-oxide; pyridine; H₂O / osmium tetroxide / 2-methyl-propan-2-ol / 8 h / 75 °C

2.1: 89 percent / DBU / dimethylformamide / 5 h / 20 °C

3.1: dibutyltin dimethoxide / dioxane / 5 h / Heating

3.2: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 2 h / 20 °C

With pyridine; water; dibutyldimethoxytin; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; osmium(VIII) oxide; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tet.2007.06.040

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 724709-46-0
3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / DBU / dimethylformamide / 5 h / 20 °C

2.1: dibutyltin dimethoxide / dioxane / 5 h / Heating

2.2: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 2 h / 20 °C

With dibutyldimethoxytin; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.06.040