131607-35-7

Upstream product

• 65475-49-2 1-(5-O-trityl-β-D-glycero-pentofuran-3-ulosyl)thymine 
• 74-95-3 1,1-dibromomethane 
• 127682-56-8 1-((2R,4S,5R)-4-Methanesulfonyl-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 724709-49-3 1-((2R,4R)-4-Benzyloxy-4-hydroxymethyl-1,7,9-trioxa-spiro[4.5]dec-2-yl)-3-benzyloxymethyl-5-methyl-1H-pyrimidine-2,4-dione 
• 853067-10-4 Toluene-4-sulfonic acid (2R,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-ylmethyl ester 
• 853067-12-6 1-((2R,4R,5R)-4-Azidomethyl-4-hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 878557-12-1 5-Methyl-1-((3R,4R,6R)-4-trityloxymethyl-1,5-dioxa-spiro[2.4]hept-6-yl)-1H-pyrimidine-2,4-dione 
• 724709-47-1 3'-O-benzyl-3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine 
• 583843-95-2 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine 
• 724709-46-0 3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)-5'-O-tritylthymidine 
• 724709-45-9 3-N-(benzyloxymethyl)-3'-C-(hydroxymethyl)-5'-O-tritylthymidine 
• 583843-97-4 3'-O,5'-O-dibenzyl-3-N-benzyloxymethyl-3'-C,4'-C-[methylenebis(oxymethyl)]thymidine 
• 583843-94-1 3'-O-benzyl-3-N-(benzyloxymethyl)-4'-C-(hydroxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine 
• 583843-92-9 3'-O-benzyl-3-N-(benzyloxymethyl)-3'-C-((methoxymethoxy)methyl)thymidine 
• 583843-93-0 (2S,3R,5R)-3-Benzyloxy-5-(3-benzyloxymethyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-methoxymethoxymethyl-tetrahydro-furan-2-carbaldehyde 
• 950755-37-0 C₃₅H₃₈N₂O₇ 
• 950755-36-9 3',5'-di-O-benzyl-3-N-(benzyloxymethyl)-3'-C-(2-hydroxyethyl)-4'-C-(p-toluenesulfonyloxymethyl)thymidine 

Relevant academic research and scientific papers

SO2-extrusion reactions of sulfonylated nucleosides: A novel strategy for the synthesis of exocyclic olefinic thymidines

Analogues of 3′-C-methylidene-2′,3′-dideoxy-5- methyluridine have been synthesized from the 3′-deoxy-3′- sulfonylated derivatives of thymidine using sulfur dioxide extrusion reaction. Georg Thieme Verlag Stuttgart.

NUCLEOSIDE ANALOGUES WHOSE SUGAR MOIETIES ARE BOUND IN S-FORM AND OLIGONUCLEOTIDE DERIVATIVES COMPRISING NUCLEOTIDE ANALOGUES THEREOF

Compounds of the following general formula (1) and salts thereof: where A represents an alkylene group having 1 to 2 carbon atoms, etc.; B represents an aromatic heterocyclic group which may have a substituent, etc.; R1 and R2 each represent a hydrogen atom, a protective group for a hydroxyl group for synthesis of nucleic acid, a phosphate group, or -P(R4)R5 [where R4 and R5 are the same or different, and each represent a hydroxyl group, a hydroxyl group protected with a protective group for synthesis of nucleic acid, a mercapto group, a mercapto group protected with a protective group for synthesis of nucleic acid, etc.]; and R3 represents a hydrogen atom, a halogen atom, a hydroxyl group, a hydroxyl group protected with a protective group for synthesis of nucleic acid, etc. These compounds are useful for producing oligonucleotide analogues useful for the antisense method, antigene method, etc., and for producing their intermediates.

SYNTHESIS OF 2',3'-DIDEOXY-3'-METHYLENE PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTI-AIDS AGENTS

Efficient synthesis of 2',3'-dideoxy-3'-methylene nucleoside analogs starting from 2'-deoxy-3'-keto-nucleosides is described.