methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate

Base Information

• Chemical Name: methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate
• CAS No.: 1309935-55-4
• Molecular Formula: C₂₆H₃₄FNO₄Si
• Molecular Weight: 471.644
• Mol file: 1309935-55-4.mol

Synonyms:methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate

Chemical Property of methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate

There total 1 articles about methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

p-(di-tert-butylfluorosilyl)benzaldehyde (915023-44-8) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate (1309935-55-4)

Guidance literature:

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester; With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at -78 ℃; for 0.5h;

p-(di-tert-butylfluorosilyl)benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 5h;

DOI:10.1002/ejic.201100142

Reference yield: 100.0%

methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate (1309935-55-4) → (S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate (1309935-56-5)

Guidance literature:

With hydrogen; In dichloromethane; for 24h; under 750.075 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/ejic.201100142

Reference yield:

methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate (1309935-55-4) → (R)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate (1309935-65-6)

Guidance literature:

With hydrogen; In dichloromethane; for 24h; under 750.075 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/ejic.201100142

upstream raw materials:

p-(di-tert-butylfluorosilyl)benzaldehyde

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

Downstream raw materials:

(S)-2-amino-3-[4-(di-tert-butylfluorosilanyl)phenyl]propionic acid

(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

(R)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

(R)-2-amino-3-[4-(di-tert-butylfluorosilanyl)phenyl]propionic acid