(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

Base Information

Chemical Name:(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate
CAS No.:1309935-56-5
Molecular Formula:C₂₆H₃₆FNO₄Si
Molecular Weight:473.66
Hs Code.:

Synonyms:(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

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Chemical Property of (S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

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Technology Process of (S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

There total 3 articles about (S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1309935-55-4
methyl Z-2-benzyloxycarbonylamino-3-[4-(di-tert-butyl-fluorosilanyl)phenyl]acrylate

: 1309935-56-5
(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

Guidance literature:: With hydrogen; In dichloromethane; for 24h; under 750.075 Torr; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/ejic.201100142

Reference yield:

: 915023-44-8
p-(di-tert-butylfluorosilyl)benzaldehyde

: 1309935-56-5
(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0.5 h / -78 °C

1.2: 5 h / -78 - 20 °C

2.1: hydrogen / dichloromethane / 24 h / 750.08 Torr

With hydrogen; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/ejic.201100142

Reference yield:

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 1309935-56-5
(S)-methyl 2-(bezyloxycarbonylamino)-3-[4-(di-tert-butylfluorosilyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0.5 h / -78 °C

1.2: 5 h / -78 - 20 °C

2.1: hydrogen / dichloromethane / 24 h / 750.08 Torr

With hydrogen; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/ejic.201100142