2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide

Base Information

• Chemical Name: 2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide
• CAS No.: 1448150-45-5
• Molecular Formula: C₂₇H₃₂ClFN₂O₂
• Molecular Weight: 471.015
• Mol file: 1448150-45-5.mol

Synonyms:2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide

Chemical Property of 2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide

There total 2 articles about 2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-((cyclohexylcarbamoyl)(2-chloro-4-fluorophenyl)methyl)-4-cyclohexyl-N-(prop-2-ynyl)but-2-ynamide (1448150-25-1) → 2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide (1448150-45-5)

Guidance literature:

With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 120 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc43418d

Reference yield:

Cyclohexyl isocyanide (931-53-3) + 4-cyclohexyl-2-butynoic acid (5962-81-2) + 2-chloro-4-fluorobenzaldehyde (84194-36-5) → 2-(2-chloro-4-fluorophenyl)-N-cyclohexyl-2-(3'-oxospiro[cyclohexane-1,6'-cyclopenta[c]pyridin]-2'(1'H,3'H,5'H)-yl)acetamide (1448150-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 20 °C / Inert atmosphere

2: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 120 °C / Inert atmosphere

With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; sodium sulfate; In methanol; 1,2-dichloro-ethane; 1: |Ugi Condensation;

DOI:10.1039/c3cc43418d

upstream raw materials:

N-((cyclohexylcarbamoyl)(2-chloro-4-fluorophenyl)methyl)-4-cyclohexyl-N-(prop-2-ynyl)but-2-ynamide

Cyclohexyl isocyanide

4-cyclohexyl-2-butynoic acid

2-chloro-4-fluorobenzaldehyde