2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol

Base Information

• Chemical Name: 2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol
• CAS No.: 925244-00-4
• Molecular Formula: C₃₀H₃₃N₃O
• Molecular Weight: 451.612
• Mol file: 925244-00-4.mol

Synonyms:2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol

Chemical Property of 2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol

There total 1 articles about 2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine (151070-87-0) + 2-bromoethanol (540-51-2) → 2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol (925244-00-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmcl.2005.10.087

Reference yield: 79.0%

2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol (925244-00-4) → 1-(2-chloro-ethyl)-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine (925245-76-7)

Guidance literature:

With thionyl chloride; In dichloromethane;

DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

2-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-ethanol (925244-00-4) → 4-(1H-Imidazol-4-ylmethyl)-1-[2-(4-piperidin-1-ylmethyl-phenoxy)-ethyl]-piperidine

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / SOCl₂ / CH₂Cl₂

2: 38 percent / NaH; KI / dimethylformamide / 50 °C

3: maleic acid / methanol / Heating

With thionyl chloride; sodium hydride; maleic acid; potassium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.10.087

upstream raw materials:

4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

2-bromoethanol

Downstream raw materials:

1-(2-chloro-ethyl)-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

1-[2-(4-Piperidin-1-ylmethyl-phenoxy)-ethyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine