N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

Base Information

Chemical Name:N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate
CAS No.:1431959-41-9
Molecular Formula:C₂HF₃O₂*C₂₀H₁₈FN₅OS
Molecular Weight:509.484
Hs Code.:

Synonyms:N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

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Chemical Property of N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

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Technology Process of N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

There total 4 articles about N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431959-92-0
C₉H₇N₃S

: 1431960-66-5
C₁₁H₁₁FN₂O

: 76-05-1
trifluoroacetic acid

: 1431959-41-9
N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

Guidance literature:: C₉H₇N₃S; C₁₁H₁₁FN₂O; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-41-9
N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 16 h / 20 °C

With dmap; triethylamine; In methanol; dichloromethane;

Reference yield:

: 1431960-65-4
C₁₆H₁₉FN₂O₃

: 1431959-41-9
N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;