2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Base Information

Chemical Name:2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone
CAS No.:105857-75-8
Molecular Formula:C₃₈H₅₈O₂S
Molecular Weight:578.943
Hs Code.:

Synonyms:2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

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Chemical Property of 2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

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Technology Process of 2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

There total 8 articles about 2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 108-98-5
thiophenol

: 105857-74-7
Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

: 105857-75-8
2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Guidance literature:: With sodium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/ja00236a034

Reference yield:

: 1117-47-1
(R)-4,8-dimethyl-1-nonanol

: 105857-75-8
2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 8 steps

1: H₂SO₄, aq HBr

2: methanol

3: LiAlH₄ / tetrahydrofuran

4: 96 percent / tetrahydrofuran / 20 h / Ambient temperature

5: 1) TMSOTf, 2) pyridine, 0.5percent NaOH in MeOH / 1) -85 deg C, 2) RT, 1 h

6: 93 percent / TiCl₄ / CH₂Cl₂ / 0.75 h / -85 °C

7: Et₃N / CH₂Cl₂ / 0 °C

8: 86 percent / NaH / tetrahydrofuran / Ambient temperature

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; hydrogen bromide; titanium tetrachloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00236a034

Reference yield:

: 81306-12-9
(R)-(-)-4,8-dimethylnonanonyl bromide

: 105857-75-8
2-[(1R,2S,5R)-1-((2R,6R)-6,10-Dimethyl-2-phenylsulfanylmethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: methanol

2: LiAlH₄ / tetrahydrofuran

3: 96 percent / tetrahydrofuran / 20 h / Ambient temperature

4: 1) TMSOTf, 2) pyridine, 0.5percent NaOH in MeOH / 1) -85 deg C, 2) RT, 1 h

5: 93 percent / TiCl₄ / CH₂Cl₂ / 0.75 h / -85 °C

6: Et₃N / CH₂Cl₂ / 0 °C

7: 86 percent / NaH / tetrahydrofuran / Ambient temperature

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; titanium tetrachloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00236a034