Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

Base Information

Chemical Name:Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester
CAS No.:105857-74-7
Molecular Formula:C₃₃H₅₆O₅S
Molecular Weight:564.871
Hs Code.:

Synonyms:Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

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Chemical Property of Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

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Technology Process of Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

There total 7 articles about Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 105857-73-6
2-[(1R,2S,5R)-1-((2S,6R)-2-Hydroxymethyl-6,10-dimethyl-undecyloxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

: 105857-74-7
Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/ja00236a034

Reference yield:

: 1117-47-1
(R)-4,8-dimethyl-1-nonanol

: 105857-74-7
Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂SO₄, aq HBr

2: methanol

3: LiAlH₄ / tetrahydrofuran

4: 96 percent / tetrahydrofuran / 20 h / Ambient temperature

5: 1) TMSOTf, 2) pyridine, 0.5percent NaOH in MeOH / 1) -85 deg C, 2) RT, 1 h

6: 93 percent / TiCl₄ / CH₂Cl₂ / 0.75 h / -85 °C

7: Et₃N / CH₂Cl₂ / 0 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; hydrogen bromide; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00236a034

Reference yield:

: 81306-12-9
(R)-(-)-4,8-dimethylnonanonyl bromide

: 105857-74-7
Methanesulfonic acid (2R,6R)-2-[(1R,2S,5R)-2-isopropyl-5-methyl-1-(2-oxo-2-phenyl-ethyl)-cyclohexyloxymethyl]-6,10-dimethyl-undecyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: methanol

2: LiAlH₄ / tetrahydrofuran

3: 96 percent / tetrahydrofuran / 20 h / Ambient temperature

4: 1) TMSOTf, 2) pyridine, 0.5percent NaOH in MeOH / 1) -85 deg C, 2) RT, 1 h

5: 93 percent / TiCl₄ / CH₂Cl₂ / 0.75 h / -85 °C

6: Et₃N / CH₂Cl₂ / 0 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00236a034