tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

Base Information

Chemical Name:tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate
CAS No.:502481-71-2
Molecular Formula:C₁₈H₂₆N₂O₆
Molecular Weight:366.414
Hs Code.:

Synonyms:tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

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Chemical Property of tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

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Technology Process of tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

There total 5 articles about tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 502481-71-2
tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / t-BuOK / dimethylformamide / 6 h / 0 °C

2: 84 percent / (Ph₃P)4Pd / dimethylformamide / 3 h / 80 °C

3: (MeO)3B; BH₃*THF / tetrahydrofuran / 5 h / 20 °C

4: 5.60 g / tetrahydrofuran / 15 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; Trimethyl borate; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l

Reference yield:

: 107-59-5
tert-Butyl chloroacetate

: 502481-71-2
tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / t-BuOK / dimethylformamide / 6 h / 0 °C

2: 84 percent / (Ph₃P)4Pd / dimethylformamide / 3 h / 80 °C

3: (MeO)3B; BH₃*THF / tetrahydrofuran / 5 h / 20 °C

4: 5.60 g / tetrahydrofuran / 15 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; Trimethyl borate; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l

Reference yield:

: 502481-69-8
tert-butyl (5-iodo-2-nitrophenyl)acetate

: 502481-71-2
tert-butyl (5-{[(tert-butoxycarbonyl)amino]methyl}-2-nitrophenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / (Ph₃P)4Pd / dimethylformamide / 3 h / 80 °C

2: (MeO)3B; BH₃*THF / tetrahydrofuran / 5 h / 20 °C

3: 5.60 g / tetrahydrofuran / 15 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; Trimethyl borate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l