7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine
CAS No.:871671-48-6
Molecular Formula:C₂₆H₃₄ClN₃O₄Si
Molecular Weight:516.112
Hs Code.:

Synonyms:7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

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Chemical Property of 7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

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Technology Process of 7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

There total 5 articles about 7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 208459-81-8
4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

: 102690-94-8
2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranosyl chloride

: 871671-48-6
7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

Guidance literature:: 4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine; With potassium hydroxide; In acetonitrile; at 20 ℃; for 2h;

2,3-O-isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranosyl chloride; In toluene; at 20 ℃; for 16h;
DOI:10.1021/jm050394a

Reference yield:

: 871671-45-3
5-phenylpyrrolo-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one

: 871671-48-6
7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84 percent / POCl₃ / 2.5 h / 120 °C

2.1: KOH; TDA-1 / acetonitrile / 2 h / 20 °C

2.2: toluene / 16 h / 20 °C

With potassium hydroxide; trichlorophosphate; In acetonitrile;
DOI:10.1021/jm050394a

Reference yield:

: 54760-24-6
2-amino-4-phenyl-1H-pyrrole-3-carboxylic acid amide

: 871671-48-6
7-(5-O-tert-butyldimethylsilyl-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-4-chloro-5-phenylpyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 16 h / 20 °C

2.1: 84 percent / POCl₃ / 2.5 h / 120 °C

3.1: KOH; TDA-1 / acetonitrile / 2 h / 20 °C

3.2: toluene / 16 h / 20 °C

With potassium hydroxide; toluene-4-sulfonic acid; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm050394a